Behavioural Influence of Atorvastatin alone and in Combination with Antiepileptics against Electroconvulsions in Mice
DOI:
https://doi.org/10.18034/mjmbr.v4i1.426Keywords:
Atorvastatin, Phenytoin, MES Convulsion, lacosamide, levetiracetam, BehaviorAbstract
The aim of the present study was to investigate the behavioral influence of atorvastatin alone and in combination with antiepileptics like lacosamide and levetiracetam in the mouse after the experimental convulsions induced by maximal electroshock method. The maximal seizure pattern was induced in mice in alternative days for upto 9 days by giving an alternating current of 45 mA for 0.2 Sec. Atorvastatin (10mg/ kg i.p) were administered intraperitoneally 30 min before the electrical induction of seizures in alone and in combination with lacosamide (10mg/kg i.p) and levetiracetam (10mg/kg i.p). Rota rod, hole board, tail suspension and were used to record behavioral effects periodically. Additionally, the effects of administration of atorvastatin on the adverse effect potential of an lacosamide and levetiracetam were assessed in the chimney test for its motor performance. The results shows that, there is a gradual significant increase of muscle grip strength (p<0.05) and reduction in immobility time (p<0.05) on the 7th day which indicates modulatory effect of atorvastatin on behavior while combining with levetiracetam and lacosamide. In hole board test there was a significant increase in head poking were observed which indicates that the given drug atorvastatin has alleviated the anxiety and depression which confirms its modulatory effects on behavior while combining with levetiracetam and lacosamide. In addition to this atorvastatin in combinations with both antiepileptic drugs had no impact on their adverse effects in the chimney test. Based on the study, the results suggest that the HMG-CoA inhibitor atorvastatin fails to protect the seizures alone and in combination with levetiracetam and shows modulatory effects on behavior while combining with antiepileptics in MES convulsion model.
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